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Horm Metab Res 2023; 55(09): 617-624
DOI: 10.1055/a-2144-7236
Original Article: Endocrine Care

Positive Effects of Physical Activity on Prescription on Glycemic Control, Fitness, and Quality of Life in Newly Diagnosed Type 2 Diabetic Patients

Tam Ngoc Nguyen
1   Department of Geriatrics, Hanoi Medical University, Hanoi, Vietnam
2   Scientific Research Department, National Geriatric Hospital, Ha Noi, Vietnam
,
Huyen Thi Thanh Vu
1   Department of Geriatrics, Hanoi Medical University, Hanoi, Vietnam
2   Scientific Research Department, National Geriatric Hospital, Ha Noi, Vietnam
,
Long Quynh Khuong
3   Faculty of Science, Hasselt University, Diepenbeek, Belgium
,
Ingeborg van der Ploeg
4   Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
,
Carl Johan Sundberg
4   Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
5   Department of Learning, Informatics, Management and Ethics, Karolinska Institute, Stockholm, Sweden
› Author Affiliations
Funding Information VR/SIDA — 348–2011–7246
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Abstract

The aim was to investigate the effects of physical activity on prescription (PAP) compared with standard care (SC) in adult drug-naïve T2D patients. A randomized control trial was conducted with drug-naïve T2D patients attending an out-patient clinic Vietnam. Participants were randomly assigned to the PAP group (n+=+44) or the SC group (n+=+43). The PAP group received individualized recommendations for PA, intensive face-to-face training every two weeks. The SC group received the standard recommendations according to WHO guidelines. The mean HbA1c level change was larger (–10.6±6.4 mmol/mol) in the PAP group than in the SC group (–2.4±5.8 mmol/mol) (p<0.001). A one thousand step counts per day increase was significantly associated with a decrease of –2.43 mmol/mol in HbA1c [β=–2.43, 95%CI: (–2.94, –1.92]) in the PAP group. The fasting plasma glucose levels of the PAP group decreased significantly compared with the SC group. The VO2-max increased significantly more in the PAP group than in the SC group. PAP had clear positive effects on health-related Quality of Life [mean between group difference: 9.54 (95%CI 5.84,13.23)]. Insulin resistance, BMI, waist circumference, total cholesterol, LDL cholesterol and triglycerides were significantly more decreased in the PAP group than in the control group. In conclusion, the fact that even a small change in mean step counts over three months had a beneficial effect on health-related outcomes in drug-naïve T2D patients can have large implications for treatment and management practices, not least in a middle-income country like Vietnam.

Key words

exercise - Vietnam - diabetes

Supplementary Material



Publication History

Received: 22 January 2023

Accepted after revision: 24 July 2023

Article published online:
07 September 2023

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